Suppression of Transfusion - Related Alloimmunization in Intensively

نویسندگان

  • Thomas V. Holohan
  • Paul I. Terasaki
  • Albert B. Deisseroth
چکیده

A retrospective review of HIA antibody testing and transfusion records of 1 00 cancer patients who required extensive platelet support revealed that 27 of 1 00 patients exhibited positive HLA antibody tests; only 13 remained positive on repetitive examination, while 88% of aplastic anemia patients so tested were positive. Sixty-five patients with leukemia, 1 6 with Ewing’s sarcoma, and 19 with recurrent undifferentiated lymphoma were studied. Each patient received at least 10 U of platelets (mean of 72). HLA antibodies were detected in 31 % (20/65) of the leukemias, 12% (2/16) of the Ewing’s. and 26% (5/19) of the lymphoma patients. Fourteen of the 27 patients who developed antibodies became antibody negative again

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تاریخ انتشار 2005